Midbrain Tet1 dosage defines inter-individual binge-eating susceptibility
Tim Gruber, Robert Chesters, Luca Fagnocchi, Xinyang Yu, Zhen Fu, Kristin L. Gallik, Heiko Backes, Robert M. Vaughan, Melanie Huber, Meri De Angelis, Josef Gullmets, Holly Dykstra, Stefanos Apostle, Taylor Cook, Justin R. Kulchycki, , John Andrew Pospisilik
This study shows that Tet1 dosage in midbrain neurons determines binge-eating susceptibility in mice and links Tet1 methylation to human binge-eating behavior.
bioRxiv · Apr 7, 2026 · PreprintNeuroscience