Heiko Backes

Midbrain Tet1 dosage defines inter-individual binge-eating susceptibility

This study shows that Tet1 dosage in midbrain neurons determines binge-eating susceptibility in mice and links Tet1 methylation to human binge-eating behavior.

A combination of the geroprotectors trametinib and rapamycin is more effective than either drug alone

This study shows that combining trametinib and rapamycin extends mouse lifespan more than either drug alone and improves health markers in older age.

The neural basis of flavour-nutrient learning

This paper identifies a dopamine pathway that enables flavour-nutrient learning by integrating interoceptive signals from the mouth and gut.

Deficiency of Orexin Receptor Type 1 in Dopaminergic Neurons Increases Novelty-Induced Locomotion and Exploration

This study shows that deleting Ox1R in dopaminergic neurons increases novelty-induced locomotion and exploration without affecting other behaviors.