Tim Gruber

This study shows that Magel2 deficiency in a mouse model of Prader-Willi syndrome causes microglial structural changes and increased synaptic engulfment, altering neuron-microglia interactions and hypothalamic circuit function.

This study shows that Tet1 dosage in midbrain neurons determines binge-eating susceptibility in mice and links Tet1 methylation to human binge-eating behavior.

This study examines the oxytocin system and OTR-expressing astrocytes in a mouse model of PWS, finding reduced oxytocin cells and OTR-expressing astrocytes in specific brain regions with sex-specific differences.

This study shows that oxytocin and cholecystokinin pathways in hypothalamic neurons are critical for gut-to-brain feeding control, with their disruption leading to hyperphagic obesity.

This study shows that a hypercaloric diet causes temporary molecular changes in astrocytes specifically in the arcuate nucleus of the hypothalamus.