Robert M. Vaughan

Midbrain Tet1 dosage defines inter-individual binge-eating susceptibility

This study shows that Tet1 dosage in midbrain neurons determines binge-eating susceptibility in mice and links Tet1 methylation to human binge-eating behavior.

Molecular dynamics simulations provide insights into ULK-101 potency and selectivity toward autophagic kinases ULK1/2

This study uses molecular dynamics simulations to analyze how ULK-101 binds to ULK1/2 kinases, revealing structural features that explain its potency and selectivity.

UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation

This study shows UHRF1 ubiquitin ligase activity and DNMT1 ubiquitin reading activity are essential for maintaining low-density CpG methylation, and their disruption leads to hypomethylation and PMD formation in cancer.

Analysis of histone antibody specificity directly in sequencing data using siQ-ChIP

This paper introduces siQ-ChIP, a method to generate quantitative ChIP-seq data without spike-in normalization and shows how antibody specificity can be analyzed directly in ChIP-seq experiments.

siQ-ChIP:A reverse-engineered quantitative framework for ChIP-sequencing

The paper introduces a quantitative framework for ChIP-seq analysis that avoids the need for spike-in reagents by leveraging competitive binding during the IP step and provides a visualization technique for richer data characterization.