Author

Melanie Rothley

Karlsruhe Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Gary R. DavidsoniD· 2 shared Janine WesslowskiiD· 2 shared Andrew C.B. CatoiD· 1 shared Barbara BellettiiD· 1 shared Christine BlattneriD· 1 shared Christoph W. GrathwoliD· 1 shared Ilenia SegattoiD· 1 shared Julia Müller· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Gary R. DavidsonORCID

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Author profile →

2 papers

Recent·Most cited

Distinct 2-phenyl-imidazo pyridine derivatives drive ER degradation and selectively impair proliferation of ER+ breast cancer cells via the aryl hydrocarbon receptor

Katrin Koellisch, Christine Blattner, Stefano Motta, Janine Wesslowski, Melanie Rothley, Simone Büchel, Savannah Sirounian, Julia Müller, Marina Grimaldi, Jutta Stober, Zoe Wammetsberger, Mengwu Pan, René Houtman, Christoph W. Grathwol, Ilenia Segatto, , Andrew C.B. Cato

The paper identifies X15695 as an AHR ligand that promotes ER degradation and inhibits ER+ breast cancer cell proliferation more effectively than fulvestrant.

bioRxiv · Jul 28, 2025 · PreprintCancer Biology

Quantification of Wnt3a, Wnt5a and Wnt16 Binding to Multiple Frizzleds Under Physiological Conditions using NanoBit/BRET

Janine Wesslowski, Sadia Safi, Michelle Rottmann, Melanie Rothley, Gary R. Davidson

This study quantifies binding affinities of Wnt3a, Wnt5a, and Wnt16 to Frizzled receptors using NanoBRET in living cells, revealing LRP6's role in modulating these interactions.

Cells · May 30, 2025Peer-reviewedBiochemistry