This study shows Wnt10b signaling prevents replication stress-induced chromosomal instability in cancer cells by suppressing microtubule dynamics and chromosome missegregation.

Life Science Alliance · Aug 22, 2025Peer-reviewedCell Biology

Distinct 2-phenyl-imidazo pyridine derivatives drive ER degradation and selectively impair proliferation of ER+ breast cancer cells via the aryl hydrocarbon receptor

Katrin Koellisch, Christine Blattner, Stefano Motta, Janine Wesslowski, Melanie Rothley, Simone Büchel, Savannah Sirounian, Julia Müller, Marina Grimaldi, Jutta Stober, Zoe Wammetsberger, Mengwu Pan, René Houtman, Christoph W. Grathwol, Ilenia Segatto, , Andrew C.B. Cato

The paper identifies X15695 as an AHR ligand that promotes ER degradation and inhibits ER+ breast cancer cell proliferation more effectively than fulvestrant.

bioRxiv · Jul 28, 2025 · PreprintCancer Biology

Quantification of Wnt3a, Wnt5a and Wnt16 Binding to Multiple Frizzleds Under Physiological Conditions using NanoBit/BRET

Janine Wesslowski, Sadia Safi, Michelle Rottmann, Melanie Rothley, Gary R. Davidson

This study quantifies binding affinities of Wnt3a, Wnt5a, and Wnt16 to Frizzled receptors using NanoBRET in living cells, revealing LRP6's role in modulating these interactions.

Cells · May 30, 2025Peer-reviewedBiochemistry

Rational Design of Unsaturated, Thioether Ionizable Lipids for Enhanced In vivo mRNA Delivery

Eleni Samaridou, Johanna Simon, Moritz Beck‐Broichsitter, Gary R. Davidson, Pavel A. Levkin

This study designs and optimizes ionizable lipids for improved in vivo mRNA delivery, achieving high efficiency and safety comparable to existing benchmarks.

Advanced Healthcare Materials · May 5, 2025Peer-reviewedBioengineering