CRY-NLRP3 complexes define a circadian checkpoint controlling inflammasome activation
Léa Bardoulet, Delphine Burlet, Hubert B. Leloup, François Virard, Sabine Hacot, Elsa Gratianne Guillot, Nouhaila El Kasmi, Camille Cosson, Lyvia Moudombi, Marie‐Cécile Michallet, Arnaud Bonnafoux, Melina Gautier, Agnès Tissier, Katja A Lamia, Bénédicte F. Py, , Anne‐Laure Huber
This study identifies CRY-NLRP3 complexes as a circadian checkpoint that modulates inflammasome activation and drug response, showing time-of-day effects on inflammation and drug efficacy.
bioRxiv · Feb 28, 2026 · PreprintImmunology