Author

Sabine Hacot

Lyon 1 Université

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:variant effect prediction· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Agnès TissieriD· 2 shared Anne‐Laure HuberiD· 2 shared Delphine Burlet· 2 shared Léa BardouletiD· 2 shared Virginie PétrilliiD· 2 shared Alex C. FaeseniD· 1 shared Arnaud Bonnafoux· 1 shared Bastian Föhr· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

Agnès TissierORCID

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2 papers

Recent·Most cited

CRY-NLRP3 complexes define a circadian checkpoint controlling inflammasome activation

Léa Bardoulet, Delphine Burlet, Hubert B. Leloup, François Virard, Sabine Hacot, Elsa Gratianne Guillot, Nouhaila El Kasmi, Camille Cosson, Lyvia Moudombi, Marie‐Cécile Michallet, Arnaud Bonnafoux, Melina Gautier, Agnès Tissier, Katja A Lamia, Bénédicte F. Py, , Anne‐Laure Huber

This study identifies CRY-NLRP3 complexes as a circadian checkpoint that modulates inflammasome activation and drug response, showing time-of-day effects on inflammation and drug efficacy.

bioRxiv · Feb 28, 2026 · PreprintImmunology

The inflammasome sensor NLRP3 interacts with REV7 to maintain genome integrity through homologous recombination

Delphine Burlet, Md Muntaz Khan, Sabine Hacot, Hannes Buthmann, Léa Bardoulet, Anne‐Laure Huber, Julie Gorry, Bastian Föhr, Bernard S. López, Yohann Couté, Alex C. Faesen, Matthias Geyer, Agnès Tissier, Virginie Pétrilli

This study shows NLRP3 promotes homologous recombination by interacting with REV7, enhancing DNA repair and affecting PARP inhibitor sensitivity.

Nucleic Acids Research · Jun 4, 2025Peer-reviewedMolecular Biology