François Virard

The paper identifies mutational signatures in cancer genomes caused by tobacco-specific nitrosamines NNN and NNK, showing their unique contribution to specific cancer types.

This study identifies CRY-NLRP3 complexes as a circadian checkpoint that modulates inflammasome activation and drug response, showing time-of-day effects on inflammation and drug efficacy.

This study identifies a non-apoptotic role for caspase-3 in melanoma cell motility by regulating coronin 1B activity, suggesting it as a potential target for anti-metastatic therapies.

This study examines the mutagenic effects of ethanol and acetaldehyde in rats, finding exposure-specific mutational signatures and suggesting inflammation or oxidative damage as key factors in alcohol-related cancers.

This study investigates the molecular and cellular responses of oral epithelial cells to arsenic and smokeless tobacco exposure using multi-omics analysis and identifies key mechanisms linked to cancer progression.