Author

Mengru Zhan

Nanjing University of Chinese Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:protein design· 2 Assay:proteomics· 2 Organism:E. coli· 1

Frequent Co-Authors

Nanxi WangiD· 2 shared Ren Xiang TaniD· 2 shared Chang ShaoiD· 1 shared Chenguang Liu· 1 shared Haiping HaoiD· 1 shared Hanqing ZhangiD· 1 shared Hui YeiD· 1 shared Jia ZhangiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersSynthetic Biology

Nanxi WangORCID

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2 papers

Recent·Most cited

In-Cell Synthesis of Nε-acetyl-L-lysine for Facile Protein Acetylation

Mengru Zhan, Yanan Zhang, Xinyi Ma, Jinyuan Xu, Yijie Lu, Jia Zhang, Shi‐Biao Wu, Jiapeng Zhu, Ren Xiang Tan, Nanxi Wang

This paper introduces a one-pot acetylation platform for site-specific protein acetylation in E. coli and mammalian cells using novel lysine acetyltransferases.

bioRxiv · Oct 29, 2025 · PreprintSynthetic Biology

Genetic code expansion reveals site-specific lactylation in living cells reshapes protein function

Chang Shao, Shuo Tang, Siqin Yu, Chenguang Liu, Yueyang Zhang, Tianyan Wan, Zimeng He, Qi Yuan, Shihan Wu, Hanqing Zhang, Ning Wan, Mengru Zhan, Ren Xiang Tan, Haiping Hao, Hui Ye, Nanxi Wang

This study uses genetic code expansion to site-specifically lactylate proteins in living cells, revealing lactylation's impact on enzyme activity and cellular function.

Nature Communications · Jan 8, 2025Peer-reviewedMolecular Biology