Author

Zimeng He

China Pharmaceutical University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Chang ShaoiD· 2 shared Haiping HaoiD· 2 shared Qi Yuan· 2 shared Yueyang ZhangiD· 2 shared Chenguang Liu· 1 shared Dexiang WangiD· 1 shared Hanqing ZhangiD· 1 shared Haoran HuangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBiochemistry

Chang ShaoORCID

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2 papers

Recent·Most cited

ChemIntelligence Enables Antibody-Free, Ultra-Low-Input Profiling of Lysine Lactylation and Diverse Acyl-Proteomes

Chang Shao, Zimeng He, Qi Yuan, Victor Giurcoiu, Xiangyu He, Xu Cao, Haoran Huang, Yuebo Zhang, Yueyang Zhang, Dexiang Wang, Qihe Jiang, Zizhang Guo, Haiping Hao, Mathias Wilhelm, Hui Ye

ChemIntelligence enables antibody-free, ultra-low-input profiling of lysine lactylation and diverse acyl-proteomes using chemical derivatization and computational methods.

bioRxiv · Aug 31, 2026 · PreprintBiochemistry

Genetic code expansion reveals site-specific lactylation in living cells reshapes protein function

Chang Shao, Shuo Tang, Siqin Yu, Chenguang Liu, Yueyang Zhang, Tianyan Wan, Zimeng He, Qi Yuan, Shihan Wu, Hanqing Zhang, Ning Wan, Mengru Zhan, Ren Xiang Tan, Haiping Hao, Hui Ye, Nanxi Wang

This study uses genetic code expansion to site-specifically lactylate proteins in living cells, revealing lactylation's impact on enzyme activity and cellular function.

Nature Communications · Jan 8, 2025Peer-reviewedMolecular Biology