Yueyang Zhang

ChemIntelligence enables antibody-free, ultra-low-input profiling of lysine lactylation and diverse acyl-proteomes using chemical derivatization and computational methods.

This study uses genetic code expansion to site-specifically lactylate proteins in living cells, revealing lactylation's impact on enzyme activity and cellular function.

This paper shows that myocardial infarction creates a time window where AAV gene therapy is more effective in mice, improving gene expression and therapeutic outcomes when administered three days post-infarction.