Chang Shao

ChemIntelligence enables antibody-free, ultra-low-input profiling of lysine lactylation and diverse acyl-proteomes using chemical derivatization and computational methods.

This paper identifies SLC13A2-transported citrate as a metabolic signal that promotes PKM2 acetylation and degradation, thereby suppressing tumor growth in hepatocellular carcinoma.

This study uses genetic code expansion to site-specifically lactylate proteins in living cells, revealing lactylation's impact on enzyme activity and cellular function.