Qi Yuan

Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene

This study identifies the RY12 domain of RyR1 as an ADP sensor and reveals dantrolene's binding mechanism through cryo-EM structures.

ChemIntelligence Enables Antibody-Free, Ultra-Low-Input Profiling of Lysine Lactylation and Diverse Acyl-Proteomes

ChemIntelligence enables antibody-free, ultra-low-input profiling of lysine lactylation and diverse acyl-proteomes using chemical derivatization and computational methods.

Probing the CaV1.2 interactome in heart failure identifies a positive modulator of inotropy and lusitropy

The paper uses proximity proteomics to study the cardiac dyad in heart failure, identifying Galectin-1 as a positive modulator of cardiac contractility and relaxation.

Prion safety laboratory swipe test

The paper describes a protocol for a prion safety laboratory swipe test to assess contamination and decontamination effectiveness in lab settings.

Genetic code expansion reveals site-specific lactylation in living cells reshapes protein function

This study uses genetic code expansion to site-specifically lactylate proteins in living cells, revealing lactylation's impact on enzyme activity and cellular function.

PDBe CCDUtils: an RDKit-based toolkit for handling and analysing small molecules in the Protein Data Bank

PDBe CCDUtils processes and analyzes small molecules from the PDB using RDKit, offering tools for property computation and database cross-references.