Coupling of oxytocin and cholecystokinin pathways in the hypothalamus is required for gut-to-brain homeostatic feeding control
Tim Gruber, F Lechner, Cahuê De Bernardis Murat, RE. Contreras, Eva Sanchez-Quant, Viktorian Miok, Ophélia Le Thuc, I González-García, Rhîannan H. Williams, Paul T. Pfluger, Timo D. Müller, SC Woods, Celia Pilar Martinez‐Jimenez, MH Tschöp, Valery Grinevich, Cristina García‐Cáceres
This study shows that oxytocin and cholecystokinin pathways in hypothalamic neurons are critical for gut-to-brain feeding control, with their disruption leading to hyperphagic obesity.
bioRxiv · Jul 20, 2022 · PreprintNeuroscience