Celia Pilar Martinez‐Jimenez

Decoding Cell-level Circadian Phase and Rhythm-state Remodeling in Single-cell Transcriptomes With scRhythmBayes

scRhythmBayes infers cell-level circadian phase and rhythm-state remodeling in single-cell transcriptomes, revealing distinct temporal patterns in liver zonation and heart disease.

Setdb1 regulates proper differentiation of adult intestinal stem cells via restraining permissive chromatin structure and transcriptional variability

This study shows that Setdb1 regulates intestinal stem cell differentiation by controlling chromatin accessibility and transcriptional variability in adult stem cells.

Spatial Transcriptomics Using Multiplexed Deterministic Barcoding in Tissue

This study introduces xDbit, a multiplexed spatial transcriptomics method, and demonstrates its application in characterizing murine kidney tissue.

Coupling of oxytocin and cholecystokinin pathways in the hypothalamus is required for gut-to-brain homeostatic feeding control

This study shows that oxytocin and cholecystokinin pathways in hypothalamic neurons are critical for gut-to-brain feeding control, with their disruption leading to hyperphagic obesity.

Single-nucleus RNA-seq2 reveals a functional crosstalk between liver zonation and ploidy

The paper develops a single-nucleus RNA-seq2 method to study ploidy and spatial zonation in hepatocytes, finding gene expression in tetraploid cells depends on their hepatic lobe position.

Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis

The paper creates a single-cell transcriptomic atlas of mouse spermatogenesis, identifying key developmental stages and X chromosome transcriptional dynamics.