Valery Grinevich

This study uses chemogenetic activation of hypothalamic oxytocin neurons in macaques to show that OT neurons increase eye-directed face exploration.

The paper shows autism-risk gene mutations disrupt oxytocin circuits in a sex-dependent manner, reducing social engagement in mouse models.

This study shows that oxytocin signaling is essential for mice to form stable social bonds in complex groups, as mice with impaired oxytocin-related social sensory processing failed to join cohesive cliques.

This study investigates how oxytocin neurons in the hypothalamus and oxytocin signaling in the nucleus accumbens regulate sex-specific social play behavior in juvenile rats.

The paper identifies FOXP1 as a key regulator of oxytocin neuron differentiation and shows its role in reducing AVP and OXT neuron abundance in knockout mice.

This study identifies a circuit in the medial prefrontal cortex where oxytocin modulates interneurons to promote social behavior in female rats, even under physiological stress.

The paper identifies a thalamic-hypothalamic circuit mediating social touch suppression of aggression in rodents using chemogenetic and optogenetic manipulations.

This study shows that oxytocin neurons in the paraventricular and supraoptic hypothalamic nuclei have opposing effects on food intake, with PVH neurons reducing meal size and SON neurons increasing it.

The paper shows that oxytocin receptor-expressing BNST neurons are excited by AVP and OT inputs, reducing anxious arousal and threat avoidance.

The paper shows that oxytocin-induced astrocyte process retraction in the amygdala modulates freezing behavior during stress by enhancing neuronal sensitivity to potassium.

The paper reports morphological evidence of low-rate neurogenesis and migration in the adult rat AVPMNS using immunohistochemical markers.

This study investigates changes in the oxytocinergic circuit in the central amygdala of rats with chronic heart failure, finding impaired OT release and receptor function.

The paper identifies stratum radiatum excitatory neurons (ExNR) as an alternative pathway for excitation in the hippocampus that bypasses perisomatic inhibition.

The paper develops a new oxytocin sensor to study compartmental OT release in neurons and finds distinct calcium channel roles and fusion machinery differences in axons and somatodendritic regions.

This study examines the oxytocin system and OTR-expressing astrocytes in a mouse model of PWS, finding reduced oxytocin cells and OTR-expressing astrocytes in specific brain regions with sex-specific differences.

The paper identifies a thalamo-preoptic pathway that controls social touch by bypassing the cerebral cortex, involving PTH2-expressing neurons and a conserved circuit across species.

This study shows that oxytocin and cholecystokinin pathways in hypothalamic neurons are critical for gut-to-brain feeding control, with their disruption leading to hyperphagic obesity.

This study identifies the supramammillary nucleus as a target of PVH oxytocin neurons and shows its necessity for social recognition memory in rats.

The paper investigates changes in the PVN-to-CA2 oxytocin pathway in heart failure rats, finding altered oxytocinergic innervation and reduced OTR-expressing astrocytes.

The paper identifies a novel analgesic pathway involving parvocellular oxytocin neurons projecting to the vlPAG, which suppresses spinal cord sensory neuron activity and alleviates pain.

This study investigates the role of oxytocin and vasopressin in female aggression using a rat model, finding that increased oxytocin in the ventral lateral septum and decreased vasopressin in the dorsal lateral septum are required for aggression.

This study shows that oxytocin acts on astrocytes in the central amygdala to promote a positive emotional state, challenging the notion that oxytocin only affects neurons.

The paper shows that specific extra-hypothalamic oxytocin neurons regulate stress-induced social anxiety behaviors by modulating social vigilance and approach.