Targeting Impaired Type I Interferon IL-27 Signaling Rescues T Regulatory Cell Suppressive Function in Relapsing-Remitting Multiple Sclerosis
Manal Elzoheiry, Maryamsadat Seyedsadr, John A. Wrobel, Yan Wang, Sowmya Shree Gopal, Ezgi Kasimoglu, Paulien Baeten, Ibrahim Hamad, Mia Rose Gleason, Bieke Broux, Jenny P.‐Y. Ting, Booki Min, Silva Markovic‐Plese
This study identifies impaired type I IFN and IL-27 signaling in RRMS Tregs and shows that cGAMP-MPs restore Treg suppressive function in EAE.
bioRxiv · Aug 26, 2025 · PreprintImmunology