Jenny P.‐Y. Ting

This study identifies folate receptor beta (FRβ) as a metabolic checkpoint on tumor-associated macrophages (TAMs) that promotes immunosuppression and tumor growth.

The paper shows that cGAS hyperactivates in response to unpaired DNA (Bu-DNA) by bending it into a V-shape, revealing a new activation mechanism.

This study identifies impaired type I IFN and IL-27 signaling in RRMS Tregs and shows that cGAMP-MPs restore Treg suppressive function in EAE.

This study shows AIM2 in CD4+ T cells drives asthma pathology in OVA-LPS and HDM models, while myeloid cell AIM2 only affects HDM-induced asthma, suggesting differential roles in disease mechanisms.