John A. Wrobel

Targeting Impaired Type I Interferon IL-27 Signaling Rescues T Regulatory Cell Suppressive Function in Relapsing-Remitting Multiple Sclerosis

This study identifies impaired type I IFN and IL-27 signaling in RRMS Tregs and shows that cGAMP-MPs restore Treg suppressive function in EAE.

T cell AIM2 Exacerbates Lung Inflammation in OVA-LPS and HDM-induced Asthma Models

This study shows AIM2 in CD4+ T cells drives asthma pathology in OVA-LPS and HDM models, while myeloid cell AIM2 only affects HDM-induced asthma, suggesting differential roles in disease mechanisms.

Targeting G9a translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae

This paper identifies G9a's role in SARS-CoV-2-induced pathogenesis by regulating translation of viral and host proteins, showing that G9a inhibitors can reverse disease-related proteomic changes.

Epigenomic, transcriptomic and proteomic characterizations of reference samples

The paper provides comprehensive reference materials with genomic, epigenomic, transcriptomic, scRNA-seq, and proteomic characterizations of two cell lines for benchmarking and validation.

TWO-SIGMA-G: A New Competitive Gene Set Testing Framework for scRNA-seq Data Accounting for Inter-Gene and Cell-Cell Correlation

TWO-SIGMA-G tests gene sets in scRNA-seq data by accounting for gene and cell correlations, showing improved power and error control in simulations and real datasets.