Ezgi Kasimoglu

This study develops a CD8 T cell-dependent model of MS and identifies differences in brain and spinal cord inflammation, showing that IFN-g and PD-1 signaling regulate CD8 T cell-mediated neuroinflammation.

This study shows that macrophage-derived extracellular vesicles promote inflammatory pain resolution via T cell-dependent immune mechanisms in mice.

This study identifies impaired type I IFN and IL-27 signaling in RRMS Tregs and shows that cGAMP-MPs restore Treg suppressive function in EAE.

This study shows that mouse serum-derived small extracellular vesicles can reduce inflammatory pain through opioid signaling and immunomodulation.