Non-Equilibrium Snapshots of Ligand Efficacy at the μ-Opioid Receptor
Michael J. Robertson, Arnab Modak, Makaía M. Papasergi-Scott, Miaohui Hu, Maria Claudia Peroto, Balázs R. Varga, Susruta Majumdar, Ravi Kalathur, Scott C. Blanchard, Georgios Skiniotis
The paper uses cryo-EM to capture non-equilibrium states of the μ-opioid receptor bound to different ligands, revealing ligand-dependent conformational dynamics and G-protein activation differences.
Nature · Dec 22, 2025Peer-reviewedPharmacology & Toxicology