Ravi Kalathur

Depth-resolved analysis reveals target-dependent cryo-FIB damage profiles

The paper analyzes depth-dependent structural damage caused by cryo-FIB milling using apoferritin as a reporter, showing damage varies with ion type and molecular target.

Cryo-EM structures of SAMD9L reveal the arrangement and coordination of multi-domains

This study determines the cryo-EM structures of hSAMD9L and an N-terminal-truncated mutant, revealing their multi-domain architecture, dimerization, and nucleotide binding properties.

Non-Equilibrium Snapshots of Ligand Efficacy at the μ-Opioid Receptor

The paper uses cryo-EM to capture non-equilibrium states of the μ-opioid receptor bound to different ligands, revealing ligand-dependent conformational dynamics and G-protein activation differences.

Midkine Attenuates Aβ Fibril Assembly and Amyloid Plaque Formation

This study shows that midkine reduces Aβ fibril formation and amyloid plaque development in Alzheimer's disease models.