Pharmacology & ToxicologyNaturePeer-reviewed
Non-Equilibrium Snapshots of Ligand Efficacy at the μ-Opioid Receptor
Michael J. Robertson, Arnab Modak, Makaía M. Papasergi-Scott…·Georgios Skiniotis
The paper uses cryo-EM to capture non-equilibrium states of the μ-opioid receptor bound to different ligands, revealing ligand-dependent conformational dynamics and G-protein activation differences.