The polyadenylase PAPI is required for virulence plasmid maintenance in pathogenic bacteria
Katherine Schubert, Jessica Zhang, Michele E. Muscolo, Micah Braly, Joshua W. McCausland, Hanh N. Lam, Karen Hug, Matthew Loven, Santiago Ruiz Solis, Melissa Estrada Escobar, Henry Moore, Derfel Terciano, Diana Fernandez Pacheco, Todd M. Lowe, Cammie F. Lesser, , Victoria Auerbuch
This study identifies PAPI (encoded by pcnB) as essential for maintaining virulence and AMR plasmid copy number, stability, and bacterial virulence in Yersinia and Shigella.
PLoS Pathogens · May 27, 2025Peer-reviewedMicrobiology