Pharmacological targeting of SOS1-RAS interaction triggers pancreatic β-cell proliferation and sustainably reverses diabetic hyperglycemia
Adriana Papadimitropoulou, Chrysanthi Charalampous, Paraskevi Kogionou, Diana Reinhardt, Johanna Sonntag, Anthony Gavalas, Marco H. Hofmann, Patrik Erlmann, Michael Franti, Jonas Doerr, Thomas Klein, Gareth R. Willis, Ioannis Serafimidis
This study shows that the SOS1-RAS inhibitor BI-3406 promotes β-cell proliferation and reverses diabetic hyperglycemia in mice.
bioRxiv · Jun 3, 2025 · PreprintCell Biology