Dysplastic Epithelial Repair Propagates Chronic Pathology Through the Paracrine Transformation of Pulmonary Fibroblasts
Nicolas P. Holcomb, Ronel Z. Samuel, Alena Klochkova, Joanna Wong, Sara Kass-Gergi, Meryl Mendoza, Michael M Maideen, Evelyn A. Martinez, Diana M Abraham, Madeline Singh, Harshini Kelam, Jarod A. Zepp, Andrew E. Vaughan
The paper shows dysplastic basal cells induce an inflammatory fibroblast phenotype through IL-1 secretion, promoting chronic inflammation and fibrosis.
bioRxiv · Apr 5, 2026 · PreprintCell Biology