Nicolas P. Holcomb

A Bioactive Phospholipid Promotes Rapid Progenitor Lung Progenitor Activation via AP-1

This study identifies lysophosphatidic acid (LPA) as a key bioactive lipid that promotes alveolar type 2 cell progenitor activation via AP-1 transcription factors during lung regeneration.

Influenza-induced tuft cell expansion alters ILC-mediated inflammation

This study shows that influenza-induced tuft cell expansion interacts with ILC2s to regulate inflammation, with tuft cell deficiency altering ILC subsets and inflammatory responses.

Dysplastic Epithelial Repair Propagates Chronic Pathology Through the Paracrine Transformation of Pulmonary Fibroblasts

The paper shows dysplastic basal cells induce an inflammatory fibroblast phenotype through IL-1 secretion, promoting chronic inflammation and fibrosis.

Disruption of Immune Responses By Type I Diabetes Exacerbates SARS-CoV-2 Mediated Lung Injury

This study shows that Type I Diabetes Mellitus worsens SARS-CoV-2-induced lung injury in mice by impairing immune responses and increasing inflammation.

ΔNp63 drives dysplastic alveolar remodeling and restricts epithelial plasticity upon severe lung injury

This study identifies ΔNp63 as a driver of dysplastic alveolar remodeling by restricting fate plasticity of p63+ progenitors in severe lung injury.

Identification of cis elements for spatio-temporal control of DNA replication

The paper identifies cis-regulatory elements (ERCEs) that control domain-wide replication timing, chromatin compartmentalization, and transcription in mouse embryonic stem cells.