Jarod A. Zepp

Dysplastic Epithelial Repair Propagates Chronic Pathology Through the Paracrine Transformation of Pulmonary Fibroblasts

The paper shows dysplastic basal cells induce an inflammatory fibroblast phenotype through IL-1 secretion, promoting chronic inflammation and fibrosis.

Airway injury induces alveolar epithelial responses mediated by macrophages

This study shows that airway injury triggers alveolar type 2 cell proliferation mediated by macrophages, revealing a myeloid-driven response in the lung.

Stc1-expressing myofibroblasts are a developmentally distinct lineage cleared through intrinsic apoptosis in the neonatal lung

This study identifies Stc1-expressing myofibroblasts as a distinct lineage that undergoes apoptosis during neonatal lung development, using genetic tools and single-cell RNA-seq.

Spatiotemporal dynamics of primary and motile cilia throughout lung development

This study investigates the spatiotemporal dynamics of primary and motile cilia during lung development, revealing distinct patterns in endothelial, epithelial, and mesenchymal cells.

Marginated neutrophils in the lungs effectively compete for nanoparticles targeted to the endothelium, serving as a part of the reticuloendothelial system

The paper shows that lung marginated neutrophils effectively uptake endothelial-targeted nanoparticles, suggesting they are part of the reticuloendothelial system.

Dynamic Hippo pathway activity underlies mesenchymal differentiation during lung alveolar morphogenesis

The paper identifies dynamic Hippo pathway activity in secondary crest myofibroblasts during lung alveolar development and shows its role in regulating lineage commitment and mesenchymal differentiation.

A CXCL12 morphogen gradient uncovers lung endothelial heterogeneity and promotes distal vascular growth

The paper identifies a CXCL12 morphogen gradient in developing pulmonary vasculature, revealing endothelial heterogeneity and its role in vascular growth.