Nuclear SUN2 coordinates endothelial cell-matrix interactions to regulate blood vessel homeostasis and barrier function
Pauline Bougaran, Danielle B. Buglak, Alexandra E. Neal, Mitesh Rathod, Michaelanthony T. Gore, Max A. Hockenberry, Aryan A. Hama Amin, Natalie T. Tanke, Morgan Oatley, Wesley R. Legant, Ziqing Liu, James E. Bear, William J. Polacheck, Victoria L. Bautch
This study shows that SUN2 in the nucleus regulates endothelial cell-matrix interactions, affecting vascular homeostasis and barrier function through microtubule and matrix metalloprotease mechanisms.
bioRxiv · May 20, 2026 · PreprintCell Biology