William J. Polacheck

This study shows that SUN2 in the nucleus regulates endothelial cell-matrix interactions, affecting vascular homeostasis and barrier function through microtubule and matrix metalloprotease mechanisms.

The paper identifies a flow-specific Notch1 mechanotransduction pathway involving receptor polarization, endocytosis, and proteolytic activation in response to fluid shear stress.

This study uses a 3D microfluidic model to investigate how uremic toxins affect monocyte-endothelial interactions under hypertension and varying matrix stiffness.

This study identifies defective endothelial mechanotransduction and hemodynamic shear stress as key drivers of PIK3CA-driven vascular malformations.