Proteostasis Stress Drives Stem Cell Aging, Clonal Hematopoiesis and Leukemia
Fanny Zhou, Michelle K. Le, Helen C. Wang, Wei Yang, Huan‐You Wang, Arukshita Tiwari, Xinjian Cen, Mary Jean Sunshine, Jeffrey A. Magee, Robert A. J. Signer
This study identifies proteostasis stress as a driver of stem cell aging, clonal hematopoiesis, and leukemia by showing Hsf1's role in both physiological adaptation and pathological clonal expansion.
bioRxiv · Nov 27, 2025 · PreprintCancer Biology