Helen C. Wang

This study shows that MLL3 and MLL4 maintain hematopoietic stem cell multipotency by opposing a B-cell default state through distinct enhancer regulation mechanisms.

This study identifies proteostasis stress as a driver of stem cell aging, clonal hematopoiesis, and leukemia by showing Hsf1's role in both physiological adaptation and pathological clonal expansion.

The paper introduces CellTag-multi, a method for multiomic single-cell lineage tracing that combines chromatin accessibility with lineage barcodes, and applies it to study reprogramming outcomes and gene regulatory programs in mouse hematopoiesis.