Jeffrey A. Magee

JARID2 Inhibition Reprograms Human Hematopoietic Progenitor Cells To Enhance Bone Marrow Transplantation

JARID2 inhibition enhances repopulating activity of human hematopoietic stem and progenitor cells in vivo via STAT1 upregulation.

MLL3 and MLL4 sustain hematopoietic stem cell multipotency by opposing a B-cell default state

This study shows that MLL3 and MLL4 maintain hematopoietic stem cell multipotency by opposing a B-cell default state through distinct enhancer regulation mechanisms.

BCLAF1 links RNA splicing to ATF4-dependent metabolic adaptation in acute myeloid leukemia

This study identifies BCLAF1 as a regulator linking RNA splicing to ATF4-dependent metabolic adaptation in AML, showing its role in sustaining leukemic cell survival and sensitivity to venetoclax.

Proteostasis Stress Drives Stem Cell Aging, Clonal Hematopoiesis and Leukemia

This study identifies proteostasis stress as a driver of stem cell aging, clonal hematopoiesis, and leukemia by showing Hsf1's role in both physiological adaptation and pathological clonal expansion.

SKIDA1 transiently sustains MLL::ENL-Expressing hematopoietic progenitors during neonatal stages and promotes B-lineage priming

This study identifies SKIDA1 as a gene promoting B-lineage priming in neonatal MLL::ENL-expressing hematopoietic progenitors, with implications for age-specific leukemogenesis.

Functional Comparison to Ezh2 Reveals PRC2-Independent Functions of Jarid2 in Hematopoietic Stem Cell Lineage Commitment

The paper compares the roles of Jarid2 and Ezh2 in hematopoiesis, finding Jarid2 has PRC2-independent functions affecting lineage commitment.

Fetal context conveys heritable protection against MLL-rearranged leukemia that depends on MLL3

The paper shows fetal exposure to MLL::ENL creates a heritable leukemia-resistant state by altering hematopoietic progenitor behavior, which can be overcome by MLL3 inactivation or cooperating mutations.

Developmental stage-specific changes in protein synthesis differentially sensitize hematopoietic stem cells and erythroid progenitors to impaired ribosome biogenesis

This study shows that developmental stage-specific changes in protein synthesis rates make hematopoietic stem cells and erythroid progenitors differentially sensitive to ribosome biogenesis defects.