Hepatic Ketogenesis Attenuates Cardiac Hypertrophy via Metabolic Reprogramming
Toshihiro Yamada, Kei Morikawa, Akira Fujiyama, Takumi Nagakura, Yuqing Xu, Miho Kataoka, Terumasa Umemoto, Miki Bundo, Kazuya Iwamoto, Zeeshan Ahmed, Suvi Linna-Kuosmanen, Shinsuke Hanatani, Hiroki Usuku, Yasushi Matsuzawa, Yasuhiro Izumiya, , Yuichiro Arima
This study shows that hepatic ketogenesis reduces cardiac hypertrophy in HFpEF by maintaining beta-hydroxybutyrate levels, which modulate myocardial metabolism.
bioRxiv · Feb 2, 2026 · PreprintBiochemistry