An in vivo model of Amyloid-Related Imaging Abnormalities (ARIA) predicts ARIA incidence of anti-Aβ antibodies seen in clinical trials
Edward D. Plowey, Jordan Abettan, Peter Cheng‐te Chou, Ming Lye‐Barthel, Ana Claudia Silva Amaral, Jennifer Sebalusky, Stefan Hamann, Jared Srinivasan, Roland Z. Brown, Qian Fang, Paul Weinreb, Dominic M. Walsh, Daniel P. Bradley, Thierry Bussière
The paper uses a mouse model to study ARIA induced by anti-Aβ antibodies, showing MRI and histopathologic features similar to human ARIA.
bioRxiv · Feb 2, 2026 · PreprintNeuroscience