David A. Joy

This study shows chronic NLRP3 inflammasome activation leads to neutrophil entry into the brain and interactions with microglia, contributing to CNS pathology.

This paper demonstrates that dual targeting of TfR and CD98hc enhances brain exposure of large molecules compared to single-target approaches.

This study shows that GPR34 regulates microglia function and loss-of-function in TREM2 KO microglia rescues cholesterol metabolism, suggesting GPR34 as a therapeutic target for Alzheimer's disease.

The paper introduces MitoProfilerHC and an open-source version of MitoProfiler to quantify mitochondrial morphology in cells using high-content analysis and napari.

This study investigates TfR-mediated BBB transport in mice across development and aging, finding elevated transport in early development and stability across adulthood, including in an AD model.

This study develops an antibody transport vehicle targeting the transferrin receptor to improve brain delivery of anti-amyloid antibodies, reducing ARIA-like lesions and vascular inflammation in a mouse model.

This study compares the biodistribution of Fc-engineered molecules targeting BBB receptors with standard antibodies, showing distinct CNS and peripheral organ targeting.

This study uses caudalized human pluripotent stem cell organoids to model neural tube axial elongation, showing gene expression patterns and morphological features similar to development.

This study shows that reducing E-cadherin in 3D encapsulated human pluripotent stem cells leads to extraembryonic fates and multilineage differentiation, mimicking early embryonic development.

This study shows that human iPSC-derived organoids can model the cooperative development of cardiac and gut tissues through paracrine signaling.