Paul H. Weinreb

An in vivo model of Amyloid-Related Imaging Abnormalities (ARIA) predicts ARIA incidence of anti-Aβ antibodies seen in clinical trials

The paper uses a mouse model to study ARIA induced by anti-Aβ antibodies, showing MRI and histopathologic features similar to human ARIA.

Aducanumab Binding to Aβ1-42 Fibrils Alters Dynamics of the N-Terminal Tail While Preserving the Fibril Core

This paper investigates how aducanumab binds to Aβ1-42 fibrils, showing it preserves the fibril core structure while altering N-terminal dynamics and reducing secondary nucleation.

Engineering anti-amyloid antibodies with transferrin receptor targeting improves brain biodistribution and mitigates ARIA

This study develops an antibody transport vehicle targeting the transferrin receptor to improve brain delivery of anti-amyloid antibodies, reducing ARIA-like lesions and vascular inflammation in a mouse model.