Author

Wanda Kwan

Denali Therapeutics (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Organism:non-human primate· 1 Assay:proteomics· 1

Frequent Co-Authors

Allisa J. Clemens· 2 shared Claire B. DiscenzaiD· 2 shared Elysia Roche· 2 shared Jason C. DugasiD· 2 shared Johann ChowiD· 2 shared Joseph W. LewcockiD· 2 shared Kapil G. GadkariD· 2 shared Mark S. DennisiD· 2 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Allisa J. Clemens

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Engineering anti-amyloid antibodies with transferrin receptor targeting improves brain biodistribution and mitigates ARIA

Michelle E. Pizzo, Edward D. Plowey, Nathalie Khoury, Wanda Kwan, Jordan Abettan, Sarah L. DeVos, Claire B. Discenza, Timothy Earr, David A. Joy, Ming Lye‐Barthel, Elysia Roche, Darren Chan, Jason C. Dugas, Kapil G. Gadkar, René Meisner, , Y. Joy Yu Zuchero

This study develops an antibody transport vehicle targeting the transferrin receptor to improve brain delivery of anti-amyloid antibodies, reducing ARIA-like lesions and vascular inflammation in a mouse model.

bioRxiv · Jul 26, 2024 · PreprintNeuroscience

Targeting Transferrin Receptor to Transport Antisense Oligonucleotides Across the Blood-Brain Barrier

Scarlett J. Barker, Mai B. Thayer, Chaeyoung Kim, David Tatarakis, Matthew J. Simon, Rebekah L. Dial, Lizanne Nilewski, Robert C. Wells, Yinhan Zhou, Megan E. Afetian, Alfred E. Chappell, Kylie S. Chew, Johann Chow, Allisa J. Clemens, Claire B. Discenza, , Sarah L. DeVos

This paper demonstrates that systemically delivered OTV, a TfR-binding molecule, effectively transports ASO across the BBB, achieving widespread and sustained knockdown of target genes in the CNS of mice and non-human primates.

bioRxiv · Apr 25, 2023 · PreprintNeuroscience