Loss of vitamin C biosynthesis protects from a parasitic infection
Gongwen Chen, Ji Hyung Jun, Tobias Wijshake, Edward Owusu Kwarteng, Yunyang Li, Minwei Yuan, Joseph Rose, Shan Li, Sarah A. Cobb, Willow Serpa, Brayden Folger, Yafeng Li, L. Li, Weina Chen, James J. Collins, , Michalis Agathocleous
This study shows that ascorbate deficiency protects mice from schistosomiasis by impairing schistosome egg production and reducing disease severity.
Proceedings of the National Academy of Sciences · Dec 23, 2025Peer-reviewedBiochemistry