Gongwen Chen

Loss of vitamin C biosynthesis protects from a parasitic infection

This study shows that ascorbate deficiency protects mice from schistosomiasis by impairing schistosome egg production and reducing disease severity.

Highly accurate protein structure prediction-based virtual docking pipeline accelerating the identification of anti-schistosomal compounds

This paper uses AlphaFold for protein structure prediction and virtual screening to identify anti-schistosomal compounds, finding seven active compounds including Carubicin hydrochloride, which targets U2AF65 and disrupts parasite splicing.