Michalis Agathocleous

This study shows that ascorbate and TET2 promote balanced hematopoiesis, which is essential for surviving malaria and reducing disease severity.

This study shows that ascorbate deficiency in hematopoietic cells promotes leukemogenesis and identifies ascorbate as a tumor suppressor metabolite in blood cancers.

This study shows that TCA cycle turning is not essential for stem and progenitor cell survival or proliferation and its loss enhances stem cell function in hematopoiesis.

The paper develops a biosensor to monitor α-ketoglutarate in human cells and identifies a mitochondrial-to-nuclear pathway regulating chromatin methylation.

This study shows that hematopoietic stem cells (HSCs) do not require fermentation or oxidation for survival and function, instead terminating glycolysis through pyruvate export.

This study shows that ascorbate deficiency protects mice from schistosomiasis by impairing schistosome egg production and reducing disease severity.