Human endogenous retrovirus envelope proteins alter extracellular vesicle cellular interactions and biodistribution
Zach Troyer, Miranda Soumakis, Erin N. Shirk, Olesia A. Gololobova, Sarah Márquez, Martina Fabiano, Bianca Cruz Pachane, Taekyung Ryu, Chan-Hyun Na, Natalie Castell, Isabella M. Baumann, Suzanne E. Queen, Joseph L. Mankowski, Kenneth Whitaker Witwer
This study engineers extracellular vesicles with Syncytin-1 to alter their biodistribution and shows improved persistence and organ targeting in non-human primates.
bioRxiv · May 5, 2026 · PreprintBioengineering