Olesia A. Gololobova

This paper provides a standardized protocol for isolating and characterizing extracellular vesicles from mouse retinal tissue, improving the study of in vivo EV biology.

This study engineers extracellular vesicles with Syncytin-1 to alter their biodistribution and shows improved persistence and organ targeting in non-human primates.

This study develops magnetically labeled iPSC-derived extracellular vesicles for MRI/MPI-guided myocardial infarction therapy, showing improved cardiac function and detectability.

The paper describes a method to isolate and characterize lipoprotein classes in plasma, revealing unique lipidomic, proteomic, and small RNA signatures for each class.

The paper presents a modified immuno-TEM protocol to analyze tetraspanin positivity in EVs and shows that CD9 and CD81 are more enriched in small EVs.

The paper identifies factors influencing RNA sorting into extracellular vesicles, finding size and structuredness significantly affect enrichment of circular and linear RNAs.

The paper analyzes extracellular vesicles from MS and control white matter to identify pathway dysregulation and cellular origin shifts associated with the disease.

The paper investigates how extracellular vesicles interact with B cells in nonhuman primates and humans, showing uptake via endocytosis and membrane fusion, and highlights potential strategies to modulate EV-B cell interactions.

SPIRFISH detects protein and RNA in single nanoparticles, revealing variability in structure and RNA packaging efficiency.