Joseph L. Mankowski

This study engineers extracellular vesicles with Syncytin-1 to alter their biodistribution and shows improved persistence and organ targeting in non-human primates.

The paper uses IVCM and deep learning to analyze corneal nerve fibers in macaques, finding reduced nerve fiber length and fractal dimension during acute SIV infection.

The paper shows SOD2 is upregulated in SIV-infected macaque brains, primarily in astrocytes, and validates this finding in HIV datasets.

The paper assembles the pig-tailed macaque genome using linked-read sequencing and HiC scaffolding, achieving chromosome-level resolution and identifying large-scale chromosomal rearrangements with humans.

The paper evaluates deep learning methods for automated measurement of macaque corneal sub-basal nerve fibers in IVCM images, showing excellent correlation with manual tracings and inter-reader consistency.

This paper demonstrates that chimpanzee iPSCs can form cross-species chimeras with rhesus macaque embryos, suggesting functional similarity between human and chimpanzee cells.