Lysosomal cystine efflux opposes mTORC1 reactivation through the TCA cycle
Patrick Jouandin, Zvonimir Marelja, Andrey A. Parkhitko, Miriam Dambowsky, John M. Asara, Ivan Nemazanyy, Christian C. Dibble, Matias Simons, Norbert Perrimon
The paper shows lysosomal cystine efflux limits TORC1 reactivation during fasting by restricting amino acid availability through TCA cycle intermediates.
bioRxiv · Apr 13, 2019 · PreprintCell Biology