Author

Zvonimir Marelja

University Hospital HeidelbergORCID 0000-0002-3702-7528Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:Drosophila· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Matias SimonsiD· 2 shared Andrey A. ParkhitkoiD· 1 shared Christian C. DibbleiD· 1 shared Hannah Hauschild· 1 shared Hetvi Gandhi· 1 shared Indira Dibra· 1 shared Ivan NemazanyyiD· 1 shared John M. AsaraiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

Matias SimonsORCID

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2 papers

Recent·Most cited

A Drosophila model for Dent disease reveals impaired ER export of Cubilin as pathogenic mechanism

Salómon Christer, Zvonimir Marelja, Hannah Hauschild, Marine Berquez, Indira Dibra, Hetvi Gandhi, Yung-Hsin Shih, Martin Helmstädter, Olivier Devuyst, Matias Simons

This paper establishes a Drosophila model for Dent disease, showing that ClC-c depletion causes Cubilin ER retention and secretory pathway defects, revealing a new pathogenic mechanism.

bioRxiv · Mar 5, 2025 · PreprintCell Biology

Lysosomal cystine efflux opposes mTORC1 reactivation through the TCA cycle

Patrick Jouandin, Zvonimir Marelja, Andrey A. Parkhitko, Miriam Dambowsky, John M. Asara, Ivan Nemazanyy, Christian C. Dibble, Matias Simons, Norbert Perrimon

The paper shows lysosomal cystine efflux limits TORC1 reactivation during fasting by restricting amino acid availability through TCA cycle intermediates.

bioRxiv · Apr 13, 2019 · PreprintCell Biology