Matias Simons

The paper develops a high-resolution imaging approach to study Wnt signaling dynamics during mouse nephron formation using reporter mice and adaptive feedback microscopy.

This paper establishes a Drosophila model for Dent disease, showing that ClC-c depletion causes Cubilin ER retention and secretory pathway defects, revealing a new pathogenic mechanism.

This study shows that both excessive and insufficient Wnt signaling disrupt ciliogenesis in human retinal epithelial cells, highlighting the interplay between Wnt and mTOR signaling.

The paper shows lysosomal cystine efflux limits TORC1 reactivation during fasting by restricting amino acid availability through TCA cycle intermediates.