Mona Grünewald

Kinesin-induced buckling reveals the limits of microtubule self-repair

This study shows that kinesin-driven microtubule buckling causes severe lattice damage that often exceeds microtubule self-repair capacity, leading to breakage, but survival is enhanced with intracellular factors.

Cytosolic factors govern vimentin network architecture and mechanics

This study reconstitutes vimentin networks in vitro using cell extracts, showing that cytosolic factors, not filament properties, determine network architecture and mechanics, which vary by cell type.

MAP65-1/PRC1 reinforces microtubules through nucleation

The paper shows MAP65-1/PRC1 promotes microtubule nucleation on damaged lattices under mechanical stress, stabilizing microtubules and reinforcing their alignment with stress.

Tau accelerates tubulin exchange in the microtubule lattice

This study shows tau accelerates tubulin exchange in microtubule lattices by stabilizing longitudinal and destabilizing lateral interactions, challenging its traditional role as a stabilizer.