Laura Schaedel

This study shows that kinesin-driven microtubule buckling causes severe lattice damage that often exceeds microtubule self-repair capacity, leading to breakage, but survival is enhanced with intracellular factors.

This study shows that multiple clustered centrosomes in antigen-presenting cells enhance T cell activation by positioning near the cell center, unlike T cells where centrosomes polarize toward the immune synapse.

This study reconstitutes vimentin networks in vitro using cell extracts, showing that cytosolic factors, not filament properties, determine network architecture and mechanics, which vary by cell type.

The paper shows MAP65-1/PRC1 promotes microtubule nucleation on damaged lattices under mechanical stress, stabilizing microtubules and reinforcing their alignment with stress.

This study shows tau accelerates tubulin exchange in microtubule lattices by stabilizing longitudinal and destabilizing lateral interactions, challenging its traditional role as a stabilizer.

This study shows that disrupting microtubules in cytotoxic T cells enhances their migration and target cell elimination in 3D environments.